STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FAM78BFamily with sequence similarity 78 member B. (261 aa)    
Predicted Functional Partners:
SPPL2B
Signal peptide peptidase like 2B.
   
  
 0.573
LOC100684659
ADAM_spacer1 domain-containing protein.
    
 
 0.532
PAPLN
Papilin, proteoglycan like sulfated glycoprotein.
    
 
 0.532
PRPF3
Pre-mRNA processing factor 3.
   
  
 0.518
WIPF1
WAS/WASL interacting protein family member 1.
   
  
 0.515
FSCN1
Fascin actin-bundling protein 1.
   
  
 0.490
LRRC17
Leucine rich repeat containing 17.
   
  
 0.488
PAQR3
Progestin and adipoQ receptor family member 3.
      
 0.476
MAP3K14
Mitogen-activated protein kinase kinase kinase 14.
   
  
 0.474
AP2A1
AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
   
  
 0.453
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.