node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRELD2 | DNAJB11 | ENSCAFP00000001013 | ENSCAFP00000041977 | Cysteine rich with EGF like domains 2. | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | 0.783 |
CRELD2 | HSP90B1 | ENSCAFP00000001013 | ENSCAFP00000057899 | Cysteine rich with EGF like domains 2. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family. | 0.625 |
CRELD2 | HSPA5 | ENSCAFP00000001013 | ENSCAFP00000029957 | Cysteine rich with EGF like domains 2. | Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. | 0.694 |
CRELD2 | MANF | ENSCAFP00000001013 | ENSCAFP00000015071 | Cysteine rich with EGF like domains 2. | Mesencephalic astrocyte derived neurotrophic factor. | 0.909 |
CRELD2 | PDIA6 | ENSCAFP00000001013 | ENSCAFP00000064087 | Cysteine rich with EGF like domains 2. | Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. | 0.717 |
CRELD2 | SDF2 | ENSCAFP00000001013 | ENSCAFP00000042499 | Cysteine rich with EGF like domains 2. | Stromal cell derived factor 2. | 0.531 |
CRELD2 | SDF2L1 | ENSCAFP00000001013 | ENSCAFP00000022567 | Cysteine rich with EGF like domains 2. | Stromal cell derived factor 2 like 1. | 0.910 |
DNAJB11 | CRELD2 | ENSCAFP00000041977 | ENSCAFP00000001013 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Cysteine rich with EGF like domains 2. | 0.783 |
DNAJB11 | EDEM1 | ENSCAFP00000041977 | ENSCAFP00000008377 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. | 0.796 |
DNAJB11 | ERP44 | ENSCAFP00000041977 | ENSCAFP00000003711 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Endoplasmic reticulum protein 44. | 0.806 |
DNAJB11 | HSP90B1 | ENSCAFP00000041977 | ENSCAFP00000057899 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family. | 0.954 |
DNAJB11 | HSPA5 | ENSCAFP00000041977 | ENSCAFP00000029957 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. | 0.988 |
DNAJB11 | HSPA9 | ENSCAFP00000041977 | ENSCAFP00000001849 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family. | 0.799 |
DNAJB11 | MANF | ENSCAFP00000041977 | ENSCAFP00000015071 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Mesencephalic astrocyte derived neurotrophic factor. | 0.918 |
DNAJB11 | PDIA6 | ENSCAFP00000041977 | ENSCAFP00000064087 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. | 0.922 |
DNAJB11 | SDF2 | ENSCAFP00000041977 | ENSCAFP00000042499 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Stromal cell derived factor 2. | 0.833 |
DNAJB11 | SDF2L1 | ENSCAFP00000041977 | ENSCAFP00000022567 | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | Stromal cell derived factor 2 like 1. | 0.846 |
EDEM1 | DNAJB11 | ENSCAFP00000008377 | ENSCAFP00000041977 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. | DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1. | 0.796 |
EDEM1 | ERP44 | ENSCAFP00000008377 | ENSCAFP00000003711 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. | Endoplasmic reticulum protein 44. | 0.471 |
EDEM1 | HSP90B1 | ENSCAFP00000008377 | ENSCAFP00000057899 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family. | 0.587 |