STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPG11SPG11 vesicle trafficking associated, spatacsin. (2458 aa)    
Predicted Functional Partners:
AP5Z1
Adaptor related protein complex 5 subunit zeta 1.
   
 
 0.959
ZFYVE26
Zinc finger FYVE-type containing 26.
   
 
 0.936
SPG21
SPG21 abhydrolase domain containing, maspardin.
   
  
 0.828
MED28
Mediator complex subunit 28.
      
 0.781
PRAF2
WD repeat domain 45.
      
 0.765
AK4
DnaJ heat shock protein family (Hsp40) member C6.
      
 0.763
AP5M1
Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family.
    
 
 0.761
SPAST
Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]
      
 0.758
SPART
Spartin.
      
 0.748
NIPA1
NIPA magnesium transporter 1.
      
 0.740
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.