STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FRMD8FERM domain containing 8. (463 aa)    
Predicted Functional Partners:
ITGB1BP1
Integrin subunit beta 1 binding protein 1.
    
 
 0.729
CCDC60
Coiled-coil domain containing 60.
      
 0.673
RHBDF2
Inactive rhomboid protein 2; Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Belongs to the peptidase S54 family.
   
  
 0.672
ADAM7
ADAM metallopeptidase domain 7.
      
 0.641
SH3PXD2A
SH3 and PX domains 2A.
   
  
 0.632
DARS1
Aspartyl-tRNA synthetase.
      
 0.515
CEP128
Centrosomal protein 128.
      
 0.499
EPGN
Epithelial mitogen.
   
  
 0.484
NEK6
NIMA related kinase 6; Belongs to the protein kinase superfamily.
      
 0.481
MRLN
Uncharacterized protein.
      
 0.479
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.