E2R7E0_CANLF protein (Canis lupus familiaris)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

E2R7E0_CANLF

Uncharacterized protein. (519 aa)

Predicted Functional Partners:

TRRAP

0.823

TAF10

0.820

SGF29

0.811

TAF6L

0.796

TAF5L

0.781

TADA3

0.748

ENSCAFP00000051035

0.748

SUPT7L

0.746

LOC608905

0.746

TADA2A

0.720

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
E2R7E0_CANLF	ENSCAFP00000051035	ENSCAFP00000020091	ENSCAFP00000051035	Uncharacterized protein.	Uncharacterized protein.	0.748
E2R7E0_CANLF	LOC608905	ENSCAFP00000020091	ENSCAFP00000035567	Uncharacterized protein.	BTP domain-containing protein.	0.746
E2R7E0_CANLF	SGF29	ENSCAFP00000020091	ENSCAFP00000025225	Uncharacterized protein.	SAGA complex associated factor 29.	0.811
E2R7E0_CANLF	SUPT7L	ENSCAFP00000020091	ENSCAFP00000032684	Uncharacterized protein.	BTP domain-containing protein.	0.746
E2R7E0_CANLF	TADA2A	ENSCAFP00000020091	ENSCAFP00000026800	Uncharacterized protein.	Transcriptional adapter.	0.720
E2R7E0_CANLF	TADA3	ENSCAFP00000020091	ENSCAFP00000031654	Uncharacterized protein.	Transcriptional adaptor 3.	0.748
E2R7E0_CANLF	TAF10	ENSCAFP00000020091	ENSCAFP00000009728	Uncharacterized protein.	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family.	0.820
E2R7E0_CANLF	TAF5L	ENSCAFP00000020091	ENSCAFP00000063099	Uncharacterized protein.	TATA-box binding protein associated factor 5 like.	0.781
E2R7E0_CANLF	TAF6L	ENSCAFP00000020091	ENSCAFP00000022995	Uncharacterized protein.	TATA-box binding protein associated factor 6 like.	0.796
E2R7E0_CANLF	TRRAP	ENSCAFP00000020091	ENSCAFP00000045167	Uncharacterized protein.	Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.	0.823
ENSCAFP00000051035	E2R7E0_CANLF	ENSCAFP00000051035	ENSCAFP00000020091	Uncharacterized protein.	Uncharacterized protein.	0.748
ENSCAFP00000051035	LOC608905	ENSCAFP00000051035	ENSCAFP00000035567	Uncharacterized protein.	BTP domain-containing protein.	0.661
ENSCAFP00000051035	SGF29	ENSCAFP00000051035	ENSCAFP00000025225	Uncharacterized protein.	SAGA complex associated factor 29.	0.931
ENSCAFP00000051035	SUPT7L	ENSCAFP00000051035	ENSCAFP00000032684	Uncharacterized protein.	BTP domain-containing protein.	0.661
ENSCAFP00000051035	TADA2A	ENSCAFP00000051035	ENSCAFP00000026800	Uncharacterized protein.	Transcriptional adapter.	0.882
ENSCAFP00000051035	TAF10	ENSCAFP00000051035	ENSCAFP00000009728	Uncharacterized protein.	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family.	0.876
ENSCAFP00000051035	TAF5L	ENSCAFP00000051035	ENSCAFP00000063099	Uncharacterized protein.	TATA-box binding protein associated factor 5 like.	0.812
ENSCAFP00000051035	TAF6L	ENSCAFP00000051035	ENSCAFP00000022995	Uncharacterized protein.	TATA-box binding protein associated factor 6 like.	0.826
ENSCAFP00000051035	TRRAP	ENSCAFP00000051035	ENSCAFP00000045167	Uncharacterized protein.	Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family.	0.876
LOC608905	E2R7E0_CANLF	ENSCAFP00000035567	ENSCAFP00000020091	BTP domain-containing protein.	Uncharacterized protein.	0.746

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.856

expected number of edges:

11

PPI enrichment p-value:

1.8e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000413

Protein peptidyl-prolyl isomerization

5 of 29

2.46

3.83

5.95e-08

GO:0006607

NLS-bearing protein import into nucleus

4 of 16

2.62

3.3

9.58e-07

GO:0051642

Centrosome localization

4 of 34

2.29

2.8

4.84e-06

GO:0006111

Regulation of gluconeogenesis

4 of 36

2.27

2.78

4.84e-06

GO:0051028

mRNA transport

5 of 83

2.0

2.74

2.06e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061665

SUMO ligase activity

4 of 13

2.71

3.52

4.17e-07

GO:0031267

Small GTPase binding

4 of 230

1.46

0.99

0.0067

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044614

Nuclear pore cytoplasmic filaments

5 of 6

3.14

6.07

1.46e-11

GO:0005642

Annulate lamellae

4 of 7

2.98

4.39

1.44e-08

GO:0106068

SUMO ligase complex

4 of 11

2.78

4.09

3.97e-08

GO:0042405

Nuclear inclusion body

4 of 11

2.78

4.09

3.97e-08

GO:0044615

Nuclear pore nuclear basket

4 of 13

2.71

4.06

3.97e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5955

Transport of Mature mRNA Derived from an Intronless Transcript

5 of 35

2.38

3.77

5.74e-08

CL:5958

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 29

2.36

3.17

1.01e-06

CL:5999

Mixed, incl. Nuclear pore central transport channel, and Nuclear pore cytoplasmic filaments

2 of 7

2.68

1.43

0.0029

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-159236

Transport of Mature mRNA derived from an Intron-Containing Transcript

5 of 60

2.14

3.22

3.24e-07

MAP-72202

Transport of Mature Transcript to Cytoplasm

5 of 65

2.11

3.18

3.24e-07

MAP-159231

Transport of Mature mRNA Derived from an Intronless Transcript

4 of 40

2.22

2.75

4.93e-06

MAP-3301854

Nuclear Pore Complex (NPC) Disassembly

4 of 41

2.21

2.74

4.93e-06

MAP-159227

Transport of the SLBP independent Mature mRNA

4 of 41

2.21

2.74

4.93e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044614

Nuclear pore cytoplasmic filaments

4 of 5

3.12

4.45

1.28e-08

GOCC:0005643

Nuclear pore

5 of 54

2.19

3.5

9.09e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045255

Ran binding protein RanBP1-like

3 of 8

2.79

2.14

0.00016

IPR000156

Ran binding domain

3 of 8

2.79

2.14

0.00016

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00160

Ran-binding domain

3 of 8

2.79

2.65

1.88e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About