STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARHGEF10Rho guanine nucleotide exchange factor 10. (377 aa)    
Predicted Functional Partners:
RAB3GAP1
RAB3 GTPase activating protein catalytic subunit 1.
      
 0.925
NDRG1
N-myc downstream regulated 1.
   
  
 0.812
GJA9
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
      
 0.736
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor 6.
   
  
 0.724
PCMTD1
Protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1.
      
 0.681
ARHGEF33
Rho guanine nucleotide exchange factor 33.
   
  
 0.673
TRIM67
Tripartite motif containing 67.
      
 0.640
RASGRP2
RAS guanyl releasing protein 2.
   
  
 0.639
NAPEPLD
N-acyl phosphatidylethanolamine phospholipase D.
   
  
 0.633
ARHGEF2
Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...]
    
 
 0.622
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.