STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
USP28Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1121 aa)    
Predicted Functional Partners:
CLSPN
Claspin.
    
 0.855
KLHL34
Kelch like family member 34.
   
 
 0.806
KLHL23
Kelch like family member 23.
    
 
 0.782
TP53BP1
Tumor protein p53 binding protein 1.
   
 
 0.752
MYC
Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity).
    
 0.735
WWP1
E3 ubiquitin-protein ligase.
   
 
 0.734
UBB
Ubiquitin B.
   
 
 0.725
LOC100685053
Ubiquitin-like domain-containing protein.
   
 
 0.724
KBTBD12
Kelch repeat and BTB domain containing 12.
   
 
 0.723
TRIP12
Thyroid hormone receptor interactor 12.
   
 
 0.717
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.