STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)    
Predicted Functional Partners:
TRAF3
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.991
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
0.983
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
0.975
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
    
 0.966
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.961
TRAF2
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 0.961
LTBR
Lymphotoxin beta receptor.
   
 0.927
MAP3K7
Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
   
0.916
MAP3K8
Mitogen-activated protein kinase kinase kinase 8.
   
0.915
TAB1
TGF-beta activated kinase 1 (MAP3K7) binding protein 1.
    
 0.913
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.