RIMKLB protein (Canis lupus familiaris) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

RIMKLB

Ribosomal modification protein rimK like family member B. (386 aa)

Predicted Functional Partners:

FOLH1

0.903

ASPA

0.902

RIMKLA

0.901

IDH3B

0.836

IDH3A

0.836

IDH3G

0.836

CS

0.834

OGDHL

0.833

OGDH

0.833

IDH1

0.820

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPA	FOLH1	ENSCAFP00000028544	ENSCAFP00000051462	Aspartoacylase.	Uncharacterized protein.	0.932
ASPA	RIMKLA	ENSCAFP00000028544	ENSCAFP00000032380	Aspartoacylase.	Ribosomal modification protein rimK like family member A.	0.904
ASPA	RIMKLB	ENSCAFP00000028544	ENSCAFP00000020456	Aspartoacylase.	Ribosomal modification protein rimK like family member B.	0.902
CS	IDH1	ENSCAFP00000049199	ENSCAFP00000020046	Citrate synthase; Belongs to the citrate synthase family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.959
CS	IDH3A	ENSCAFP00000049199	ENSCAFP00000020880	Citrate synthase; Belongs to the citrate synthase family.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.938
CS	IDH3B	ENSCAFP00000049199	ENSCAFP00000009923	Citrate synthase; Belongs to the citrate synthase family.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.726
CS	IDH3G	ENSCAFP00000049199	ENSCAFP00000028461	Citrate synthase; Belongs to the citrate synthase family.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.741
CS	OGDH	ENSCAFP00000049199	ENSCAFP00000065204	Citrate synthase; Belongs to the citrate synthase family.	Transket_pyr domain-containing protein.	0.879
CS	OGDHL	ENSCAFP00000049199	ENSCAFP00000010060	Citrate synthase; Belongs to the citrate synthase family.	Oxoglutarate dehydrogenase like.	0.777
CS	RIMKLB	ENSCAFP00000049199	ENSCAFP00000020456	Citrate synthase; Belongs to the citrate synthase family.	Ribosomal modification protein rimK like family member B.	0.834
FOLH1	ASPA	ENSCAFP00000051462	ENSCAFP00000028544	Uncharacterized protein.	Aspartoacylase.	0.932
FOLH1	RIMKLA	ENSCAFP00000051462	ENSCAFP00000032380	Uncharacterized protein.	Ribosomal modification protein rimK like family member A.	0.907
FOLH1	RIMKLB	ENSCAFP00000051462	ENSCAFP00000020456	Uncharacterized protein.	Ribosomal modification protein rimK like family member B.	0.903
IDH1	CS	ENSCAFP00000020046	ENSCAFP00000049199	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Citrate synthase; Belongs to the citrate synthase family.	0.959
IDH1	IDH3A	ENSCAFP00000020046	ENSCAFP00000020880	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.980
IDH1	IDH3B	ENSCAFP00000020046	ENSCAFP00000009923	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.978
IDH1	IDH3G	ENSCAFP00000020046	ENSCAFP00000028461	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.979
IDH1	OGDH	ENSCAFP00000020046	ENSCAFP00000065204	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Transket_pyr domain-containing protein.	0.980
IDH1	OGDHL	ENSCAFP00000020046	ENSCAFP00000010060	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Oxoglutarate dehydrogenase like.	0.971
IDH1	RIMKLB	ENSCAFP00000020046	ENSCAFP00000020456	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Ribosomal modification protein rimK like family member B.	0.820

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.866

expected number of edges:

14

PPI enrichment p-value:

1.64e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006418

tRNA aminoacylation for protein translation

6 of 43

2.41

4.56

7.38e-10

GO:0006264

Mitochondrial DNA replication

3 of 11

2.7

2.38

4.02e-05

GO:0106074

aminoacyl-tRNA metabolism involved in translational fidelity

3 of 13

2.63

2.3

5.61e-05

GO:0006419

alanyl-tRNA aminoacylation

2 of 2

3.26

1.79

0.00059

GO:0009059

Macromolecule biosynthetic process

9 of 1607

1.01

1.08

9.67e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004812

aminoacyl-tRNA ligase activity

6 of 45

2.39

4.87

1.31e-10

GO:0140640

Catalytic activity, acting on a nucleic acid

10 of 542

1.53

2.99

6.88e-12

GO:0140098

Catalytic activity, acting on RNA

7 of 336

1.58

2.47

7.14e-08

GO:0002161

aminoacyl-tRNA editing activity

3 of 15

2.56

2.35

4.18e-05

GO:0000049

tRNA binding

4 of 94

1.89

1.99

6.27e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017101

aminoacyl-tRNA synthetase multienzyme complex

3 of 12

2.66

2.21

8.39e-05

GO:0005760

Gamma DNA polymerase complex

2 of 3

3.09

1.64

0.0011

GO:0042645

Mitochondrial nucleoid

3 of 40

2.14

1.54

0.0011

GO:0005739

Mitochondrion

7 of 1640

0.89

0.71

0.0018

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31610802

(2019) Aminoacyl tRNA synthetases as potential drug targets of the Panthera pathogen Babesia.

4 of 17

2.64

2.58

1.63e-05

PMID:29579307

(2018) A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.

3 of 11

2.7

1.58

0.0013

PMID:26109058

(2015) Nuclear respiratory factor 2 induces SIRT3 expression.

3 of 20

2.44

1.33

0.0035

PMID:22386318

(2012) Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression.

3 of 19

2.46

1.33

0.0035

PMID:37148543

(2023) Induction of endoplasmic reticulum stress is associated with the anti-tumor activity of monepantel across cancer types.

3 of 23

2.38

1.32

0.0036

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1857

Aminoacyl-tRNA biosynthesis

6 of 30

2.56

5.3

4.26e-11

CL:1863

aminoacyl-tRNA synthetase multienzyme complex

4 of 5

3.17

4.61

3.85e-09

CL:2589

Mitochondrial transcription, and Gamma DNA polymerase complex

4 of 11

2.82

4.03

3.24e-08

CL:1899

alanyl-tRNA aminoacylation, and threonyl-tRNA aminoacylation

2 of 5

2.87

1.49

0.0020

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cfa00970

Aminoacyl-tRNA biosynthesis

6 of 36

2.49

5.53

8.44e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0017101

aminoacyl-tRNA synthetase multienzyme complex

4 of 13

2.75

3.59

2.06e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0030

Aminoacyl-tRNA synthetase

5 of 18

2.71

5.07

2.27e-10

KW-0648

Protein biosynthesis

5 of 75

2.09

3.4

5.33e-08

KW-0820

tRNA-binding

3 of 10

2.74

2.95

3.52e-06

KW-0067

ATP-binding

5 of 770

1.08

0.84

0.0026

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01411

tRNA synthetases class II (A)

2 of 3

3.09

1.22

0.0062

PF09334

tRNA synthetases class I (M)

2 of 8

2.66

1.02

0.0139

PF03129

Anticodon binding domain

2 of 10

2.56

1.02

0.0139

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00991

A conserved domain of 46 amino acids, called WHEP-TRS has been shown PUBMED:1756734 to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to six times in the several enzymes. There are three copies in ...

2 of 6

2.79

1.22

0.0061

SM00863

Threonyl and Alanyl tRNA synthetase second additional domain

2 of 6

2.79

1.22

0.0061

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