STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GPHA2Glycoprotein hormone subunit alpha 2. (127 aa)    
Predicted Functional Partners:
GPHB5
Glycoprotein hormone subunit beta 5.
    
 0.969
CGA
Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
     
 0.704
C12orf43
Chromosome 12 open reading frame 43.
      
 0.704
ANKRD13A
Ankyrin repeat domain 13A.
      
 0.704
MMAB
Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.
    
 
 0.640
TSHB
Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism.
    
 0.581
PPP2R5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
   
 
 0.568
PRL
Prolactin.
      
 0.562
CAPN6
Calpain 6; Belongs to the peptidase C2 family.
    
 
 0.524
GIT2
GIT ArfGAP 2.
    
 
 0.518
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.