STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDCP1CUB domain containing protein 1. (832 aa)    
Predicted Functional Partners:
EPHA2
EPH receptor A2.
   
 
 0.583
EGFR
Receptor protein-tyrosine kinase.
   
 
 0.569
PRKCD
Protein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates the promoter of [...]
   
 
 0.518
PTOV1
PTOV1 extended AT-hook containing adaptor protein.
      
 0.501
SRC
Tyrosine-protein kinase.
   
 
 0.497
POLR1E
RNA polymerase I subunit E.
      
 0.495
C1R
Complement C1r; Belongs to the peptidase S1 family.
      
 0.483
PLGRKT
Plasminogen receptor with a C-terminal lysine.
      
 0.469
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
   
  
 0.459
CCL23
SCY domain-containing protein.
      
 0.457
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.