STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OSBPL1AOxysterol-binding protein; Belongs to the OSBP family. (934 aa)    
Predicted Functional Partners:
RAB7A
Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...]
   
 0.951
MOSPD2
Motile sperm domain containing 2.
   
 
 0.876
RILP
Rab interacting lysosomal protein.
   
 0.717
VAPA
VAMP associated protein A.
   
 
 0.651
ABT1
Activator of basal transcription 1.
   
  
 0.644
GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial.
   
  
 0.531
RAB20
RAB20, member RAS oncogene family.
      
 0.518
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4.
   
  
 0.516
ANAPC11
Anaphase promoting complex subunit 11.
      
 0.515
ZNF621
Zinc finger protein 621.
      
 0.515
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.