STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ASB16Ankyrin repeat and SOCS box containing 16. (453 aa)    
Predicted Functional Partners:
ASB12
Ankyrin repeat and SOCS box containing 12.
  
 
 0.676
ASB1
Ankyrin repeat and SOCS box containing 1.
  
  
0.580
ASB5
Ankyrin repeat and SOCS box containing 5.
  
 
0.567
COMMD8
COMM domain containing 8.
   
  0.545
ASB2
Ankyrin repeat and SOCS box containing 2.
  
 
 
0.541
NEDD8
NEDD8 ubiquitin like modifier.
   
  0.540
ASB9
Ankyrin repeat and SOCS box containing 9.
  
 
0.535
COMMD9
COMM domain containing 9.
   
  0.532
COMMD1
COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF- kappa-B activity. Involved in the regulation of membrane expression and ubiquiti [...]
    
  0.529
COMMD4
COMM domain containing 4.
    
 0.528
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.