STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2586 aa)    
Predicted Functional Partners:
ITGA5
Integrin subunit alpha 5; Belongs to the integrin alpha chain family.
   
 0.997
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
   
 0.995
ITGB3
Integrin beta; Belongs to the integrin beta chain family.
   
 0.995
ITGAV
Integrin subunit alpha V; Belongs to the integrin alpha chain family.
   
 0.991
SDC4
Syndecan 4.
   
 
 0.975
SDC1
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
   
 0.975
ITGB7
Integrin beta; Belongs to the integrin beta chain family.
    
 0.971
ITGA2B
Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.
   
 0.968
ITGA8
Integrin subunit alpha 8; Belongs to the integrin alpha chain family.
   
 0.962
ITGA3
Integrin subunit alpha 3; Belongs to the integrin alpha chain family.
    
 0.958
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.