node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDNF | PSAP | ENSCAFP00000007019 | ENSCAFP00000021252 | Cerebral dopamine neurotrophic factor. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.681 |
CHID1 | PSAP | ENSCAFP00000014094 | ENSCAFP00000021252 | Chitinase domain containing 1; Belongs to the glycosyl hydrolase 18 family. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.754 |
CTSD | GBA | ENSCAFP00000014791 | ENSCAFP00000025007 | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | Glucosylceramidase. | 0.461 |
CTSD | GRN | ENSCAFP00000014791 | ENSCAFP00000020876 | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | Granulin precursor. | 0.785 |
CTSD | LAMP1 | ENSCAFP00000014791 | ENSCAFP00000009494 | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | Lysosomal associated membrane protein 1. | 0.968 |
CTSD | PSAP | ENSCAFP00000014791 | ENSCAFP00000021252 | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.681 |
CTSD | SORT1 | ENSCAFP00000014791 | ENSCAFP00000048566 | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | Sortilin. | 0.608 |
GALC | GBA | ENSCAFP00000031633 | ENSCAFP00000025007 | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity); Belongs to the glycosyl hydrolase 59 family. | Glucosylceramidase. | 0.943 |
GALC | PSAP | ENSCAFP00000031633 | ENSCAFP00000021252 | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity); Belongs to the glycosyl hydrolase 59 family. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.817 |
GBA | CTSD | ENSCAFP00000025007 | ENSCAFP00000014791 | Glucosylceramidase. | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.461 |
GBA | GALC | ENSCAFP00000025007 | ENSCAFP00000031633 | Glucosylceramidase. | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (By similarity); Belongs to the glycosyl hydrolase 59 family. | 0.943 |
GBA | LAMP1 | ENSCAFP00000025007 | ENSCAFP00000009494 | Glucosylceramidase. | Lysosomal associated membrane protein 1. | 0.539 |
GBA | PSAP | ENSCAFP00000025007 | ENSCAFP00000021252 | Glucosylceramidase. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.935 |
GPR37 | GPR37L1 | ENSCAFP00000002555 | ENSCAFP00000034693 | G protein-coupled receptor 37. | G protein-coupled receptor 37 like 1. | 0.550 |
GPR37 | PSAP | ENSCAFP00000002555 | ENSCAFP00000021252 | G protein-coupled receptor 37. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.862 |
GPR37L1 | GPR37 | ENSCAFP00000034693 | ENSCAFP00000002555 | G protein-coupled receptor 37 like 1. | G protein-coupled receptor 37. | 0.550 |
GPR37L1 | PSAP | ENSCAFP00000034693 | ENSCAFP00000021252 | G protein-coupled receptor 37 like 1. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.950 |
GRN | CTSD | ENSCAFP00000020876 | ENSCAFP00000014791 | Granulin precursor. | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.785 |
GRN | LAMP1 | ENSCAFP00000020876 | ENSCAFP00000009494 | Granulin precursor. | Lysosomal associated membrane protein 1. | 0.719 |
GRN | PSAP | ENSCAFP00000020876 | ENSCAFP00000021252 | Granulin precursor. | Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. | 0.694 |