ANAPC16 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

ANAPC16

Anaphase promoting complex subunit 16. (110 aa)

Predicted Functional Partners:

ANAPC7

0.998

CDC16

0.997

CDC27

0.997

ANAPC10

0.994

ANAPC5

0.993

ANAPC15

0.989

CDC26

0.987

ANAPC1

0.987

CDC23

0.986

ANAPC11

0.984

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANAPC1	ANAPC10	ENSCAFP00000057084	ENSCAFP00000011229	Anaphase promoting complex subunit 1.	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	0.999
ANAPC1	ANAPC11	ENSCAFP00000057084	ENSCAFP00000008791	Anaphase promoting complex subunit 1.	Anaphase promoting complex subunit 11.	0.997
ANAPC1	ANAPC15	ENSCAFP00000057084	ENSCAFP00000008648	Anaphase promoting complex subunit 1.	Anaphase promoting complex subunit 15.	0.979
ANAPC1	ANAPC16	ENSCAFP00000057084	ENSCAFP00000021281	Anaphase promoting complex subunit 1.	Anaphase promoting complex subunit 16.	0.987
ANAPC1	ANAPC5	ENSCAFP00000057084	ENSCAFP00000012213	Anaphase promoting complex subunit 1.	Anaphase promoting complex subunit 5.	0.999
ANAPC1	ANAPC7	ENSCAFP00000057084	ENSCAFP00000012409	Anaphase promoting complex subunit 1.	Anaphase promoting complex subunit 7.	0.996
ANAPC1	CDC16	ENSCAFP00000057084	ENSCAFP00000009724	Anaphase promoting complex subunit 1.	Cell division cycle 16.	0.998
ANAPC1	CDC23	ENSCAFP00000057084	ENSCAFP00000001725	Anaphase promoting complex subunit 1.	Cell division cycle 23.	0.999
ANAPC1	CDC26	ENSCAFP00000057084	ENSCAFP00000040407	Anaphase promoting complex subunit 1.	Cell division cycle 26.	0.998
ANAPC1	CDC27	ENSCAFP00000057084	ENSCAFP00000020216	Anaphase promoting complex subunit 1.	Cell division cycle 27.	0.999
ANAPC10	ANAPC1	ENSCAFP00000011229	ENSCAFP00000057084	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase promoting complex subunit 1.	0.999
ANAPC10	ANAPC11	ENSCAFP00000011229	ENSCAFP00000008791	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase promoting complex subunit 11.	0.998
ANAPC10	ANAPC15	ENSCAFP00000011229	ENSCAFP00000008648	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase promoting complex subunit 15.	0.994
ANAPC10	ANAPC16	ENSCAFP00000011229	ENSCAFP00000021281	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase promoting complex subunit 16.	0.994
ANAPC10	ANAPC5	ENSCAFP00000011229	ENSCAFP00000012213	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase promoting complex subunit 5.	0.997
ANAPC10	ANAPC7	ENSCAFP00000011229	ENSCAFP00000012409	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Anaphase promoting complex subunit 7.	0.997
ANAPC10	CDC16	ENSCAFP00000011229	ENSCAFP00000009724	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle 16.	0.994
ANAPC10	CDC23	ENSCAFP00000011229	ENSCAFP00000001725	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle 23.	0.997
ANAPC10	CDC26	ENSCAFP00000011229	ENSCAFP00000040407	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle 26.	0.997
ANAPC10	CDC27	ENSCAFP00000011229	ENSCAFP00000020216	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.	Cell division cycle 27.	0.999

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Network Stats

number of nodes:

8

number of edges:

15

average node degree:

3.75

avg. local clustering coefficient:

0.845

expected number of edges:

8

PPI enrichment p-value:

0.016

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 99

1.21

1.73

4.85e-09

GO:0010467

Gene expression

11 of 163

1.04

1.32

4.85e-09

GO:0009059

Macromolecule biosynthetic process

11 of 175

1.0

1.25

4.85e-09

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 220

0.91

1.04

1.66e-08

GO:0044238

Primary metabolic process

11 of 726

0.39

0.32

0.0027

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 51

1.5

2.9

5.06e-12

GO:0019843

rRNA binding

7 of 39

1.46

2.12

2.20e-07

GO:0003676

Nucleic acid binding

8 of 267

0.68

0.52

0.0029

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015934

Large ribosomal subunit

5 of 8

2.0

3.29

4.99e-08

GO:0005840

Ribosome

10 of 53

1.48

2.91

1.22e-12

GO:0032991

Protein-containing complex

6 of 96

1.0

0.97

9.49e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:140

rRNA-binding

6 of 14

1.84

3.25

8.57e-09

CL:103

Structural molecule activity

10 of 45

1.55

3.21

7.17e-13

CL:143

Large ribosomal subunit, and Translation protein, beta-barrel domain superfamily

4 of 5

2.11

2.79

1.82e-06

CL:107

Structural molecule activity

7 of 32

1.55

2.57

8.82e-09

CL:89

Structural molecule activity, and Translation regulator activity

11 of 75

1.37

2.52

6.94e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

cgo03010

Ribosome

10 of 52

1.49

2.94

1.12e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

7 of 39

1.46

2.1

2.65e-07

GOCC:0043229

Intracellular organelle

10 of 178

0.96

1.08

2.65e-07

GOCC:0022625

Cytosolic large ribosomal subunit

2 of 4

1.91

0.96

0.0140

GOCC:0005622

Intracellular

11 of 755

0.37

0.31

0.0029

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 55

1.47

2.8

3.52e-12

KW-0699

rRNA-binding

7 of 38

1.47

2.23

6.57e-08

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