STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLHL20Kelch like family member 20. (591 aa)    
Predicted Functional Partners:
CUL3
Cullin 3; Belongs to the cullin family.
   
 0.960
KLHDC2
Kelch domain containing 2.
   
  
 0.878
KLHDC1
Kelch domain containing 1.
   
  
 0.877
NAE1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
   
 
 0.876
HNRNPA2B1
Heterogeneous nuclear ribonucleoprotein A2/B1.
 
 
    0.812
RBX1
Ring-box 1.
    
 0.757
CORO7
Coronin; Belongs to the WD repeat coronin family.
    
 
 0.729
KANK1
KN motif and ankyrin repeat domains 1.
   
 
 0.719
RNF166
Ring finger protein 166.
   
 
 0.680
NEDD8
NEDD8 ubiquitin like modifier.
   
 0.673
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.