ADRA2C protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ADRA2C

Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family. (454 aa)

Predicted Functional Partners:

GNA12

0.915

GNA13

0.913

GNAQ

0.911

GNA11

0.911

SFTPC

0.755

RAB40B

0.674

ADCY4

0.672

GNB3

0.646

GNG4

0.644

GNG2

0.644

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY4	ADRA2C	ENSCAFP00000018143	ENSCAFP00000021531	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	0.672
ADCY4	GNB3	ENSCAFP00000018143	ENSCAFP00000058821	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.682
ADCY4	GNG2	ENSCAFP00000018143	ENSCAFP00000042834	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.752
ADCY4	GNG4	ENSCAFP00000018143	ENSCAFP00000037704	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.691
ADRA2C	ADCY4	ENSCAFP00000021531	ENSCAFP00000018143	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.672
ADRA2C	GNA11	ENSCAFP00000021531	ENSCAFP00000050168	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.911
ADRA2C	GNA12	ENSCAFP00000021531	ENSCAFP00000037852	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 12.	0.915
ADRA2C	GNA13	ENSCAFP00000021531	ENSCAFP00000016361	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	G protein subunit alpha 13.	0.913
ADRA2C	GNAQ	ENSCAFP00000021531	ENSCAFP00000028446	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.	0.911
ADRA2C	GNB3	ENSCAFP00000021531	ENSCAFP00000058821	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.646
ADRA2C	GNG2	ENSCAFP00000021531	ENSCAFP00000042834	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.644
ADRA2C	GNG4	ENSCAFP00000021531	ENSCAFP00000037704	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.644
ADRA2C	RAB40B	ENSCAFP00000021531	ENSCAFP00000036681	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	RAB40B, member RAS oncogene family.	0.674
ADRA2C	SFTPC	ENSCAFP00000021531	ENSCAFP00000061434	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	Pulmonary surfactant-associated protein C.	0.755
GNA11	ADRA2C	ENSCAFP00000050168	ENSCAFP00000021531	Uncharacterized protein.	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	0.911
GNA11	GNAQ	ENSCAFP00000050168	ENSCAFP00000028446	Uncharacterized protein.	Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.	0.909
GNA11	GNB3	ENSCAFP00000050168	ENSCAFP00000058821	Uncharacterized protein.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.701
GNA11	GNG2	ENSCAFP00000050168	ENSCAFP00000042834	Uncharacterized protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.748
GNA11	GNG4	ENSCAFP00000050168	ENSCAFP00000037704	Uncharacterized protein.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.619
GNA12	ADRA2C	ENSCAFP00000037852	ENSCAFP00000021531	G protein subunit alpha 12.	Adrenoceptor alpha 2C; Belongs to the G-protein coupled receptor 1 family.	0.915