LRPAP1 protein (Canis lupus familiaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

LRPAP1

LDL receptor related protein associated protein 1. (594 aa)

Predicted Functional Partners:

LRP1

0.964

LRP2

0.960

ENSCAFP00000064467

0.778

ENSCAFP00000059683

0.767

ENSCAFP00000063111

0.767

HSD11B2

0.766

CREB3L1

0.723

SORL1

0.720

LRP8

0.714

KIAA1217

0.707

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREB3L1	HSD11B2	ENSCAFP00000013655	ENSCAFP00000030193	cAMP responsive element binding protein 3 like 1.	Hydroxysteroid 11-beta dehydrogenase 2.	0.692
CREB3L1	LRPAP1	ENSCAFP00000013655	ENSCAFP00000021550	cAMP responsive element binding protein 3 like 1.	LDL receptor related protein associated protein 1.	0.723
ENSCAFP00000059683	LRPAP1	ENSCAFP00000059683	ENSCAFP00000021550	Tr-type G domain-containing protein.	LDL receptor related protein associated protein 1.	0.767
ENSCAFP00000063111	LRPAP1	ENSCAFP00000063111	ENSCAFP00000021550	annotation not available	LDL receptor related protein associated protein 1.	0.767
ENSCAFP00000064467	LRPAP1	ENSCAFP00000064467	ENSCAFP00000021550	annotation not available	LDL receptor related protein associated protein 1.	0.778
HSD11B2	CREB3L1	ENSCAFP00000030193	ENSCAFP00000013655	Hydroxysteroid 11-beta dehydrogenase 2.	cAMP responsive element binding protein 3 like 1.	0.692
HSD11B2	LRPAP1	ENSCAFP00000030193	ENSCAFP00000021550	Hydroxysteroid 11-beta dehydrogenase 2.	LDL receptor related protein associated protein 1.	0.766
KIAA1217	LRPAP1	ENSCAFP00000048454	ENSCAFP00000021550	KIAA1217.	LDL receptor related protein associated protein 1.	0.707
LRP1	LRP2	ENSCAFP00000039944	ENSCAFP00000017993	LDL receptor related protein 1.	LDL receptor related protein 2.	0.903
LRP1	LRPAP1	ENSCAFP00000039944	ENSCAFP00000021550	LDL receptor related protein 1.	LDL receptor related protein associated protein 1.	0.964
LRP2	LRP1	ENSCAFP00000017993	ENSCAFP00000039944	LDL receptor related protein 2.	LDL receptor related protein 1.	0.903
LRP2	LRPAP1	ENSCAFP00000017993	ENSCAFP00000021550	LDL receptor related protein 2.	LDL receptor related protein associated protein 1.	0.960
LRP8	LRPAP1	ENSCAFP00000061704	ENSCAFP00000021550	LDL receptor related protein 8.	LDL receptor related protein associated protein 1.	0.714
LRPAP1	CREB3L1	ENSCAFP00000021550	ENSCAFP00000013655	LDL receptor related protein associated protein 1.	cAMP responsive element binding protein 3 like 1.	0.723
LRPAP1	ENSCAFP00000059683	ENSCAFP00000021550	ENSCAFP00000059683	LDL receptor related protein associated protein 1.	Tr-type G domain-containing protein.	0.767
LRPAP1	ENSCAFP00000063111	ENSCAFP00000021550	ENSCAFP00000063111	LDL receptor related protein associated protein 1.	annotation not available	0.767
LRPAP1	ENSCAFP00000064467	ENSCAFP00000021550	ENSCAFP00000064467	LDL receptor related protein associated protein 1.	annotation not available	0.778
LRPAP1	HSD11B2	ENSCAFP00000021550	ENSCAFP00000030193	LDL receptor related protein associated protein 1.	Hydroxysteroid 11-beta dehydrogenase 2.	0.766
LRPAP1	KIAA1217	ENSCAFP00000021550	ENSCAFP00000048454	LDL receptor related protein associated protein 1.	KIAA1217.	0.707
LRPAP1	LRP1	ENSCAFP00000021550	ENSCAFP00000039944	LDL receptor related protein associated protein 1.	LDL receptor related protein 1.	0.964

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

14

PPI enrichment p-value:

1.87e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030216

Keratinocyte differentiation

4 of 69

2.03

1.79

0.00028

GO:0043588

Skin development

5 of 156

1.77

1.76

0.00015

GO:0006672

Ceramide metabolic process

4 of 86

1.93

1.66

0.00043

GO:0031424

Keratinization

3 of 28

2.29

1.57

0.0011

GO:0046513

Ceramide biosynthetic process

3 of 51

2.03

1.29

0.0032

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28815464

(2018) Inherited Nonsyndromic Ichthyoses: An Update on Pathophysiology, Diagnosis and Treatment.

8 of 12

3.09

9.46

1.74e-18

PMID:31833240

(2020) Targeted regions sequencing identified four novel PNPLA1 mutations in two Chinese families with autosomal recessive congenital ichthyosis.

8 of 26

2.75

8.13

1.25e-16

PMID:28249031

(2017) A de novo variant in the ASPRV1 gene in a dog with ichthyosis.

6 of 11

3.0

6.41

1.16e-12

PMID:28122049

(2017) A Defect in NIPAL4 Is Associated with Autosomal Recessive Congenital Ichthyosis in American Bulldogs.

6 of 12

2.96

6.36

1.30e-12

PMID:34599683

(2021) A frameshift insertion in FA2H causes a recessively inherited form of ichthyosis congenita in Chianina cattle.

5 of 8

3.06

5.22

2.44e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:33340

Mixed, incl. Magnesium ion transmembrane transport, and Keratinization

7 of 10

3.11

8.57

1.06e-16

CL:33344

Mixed, incl. Keratinization, and Apolipoprotein A-I receptor binding

5 of 5

3.26

6.13

6.22e-12

CL:13676

Mixed, incl. Winged helix Storkhead-box1 domain, and Hemimethylated DNA-binding protein YccV like

2 of 6

2.79

1.33

0.0038

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