STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMX1Thioredoxin related transmembrane protein 1. (278 aa)    
Predicted Functional Partners:
LOC476445
IRG-type G domain-containing protein.
   
 
 0.819
LOC481472
IRG-type G domain-containing protein.
   
 
 0.819
COPS5
COP9 signalosome subunit 5.
   
 
 0.739
IFGGB1
IRG-type G domain-containing protein.
   
 
 0.696
ARMC10
Armadillo repeat containing 10.
   
 
 0.687
IFGGC1
IRG-type G domain-containing protein.
   
 
 0.668
CANX
Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...]
   
 
 0.651
CDK5RAP3
CDK5 regulatory subunit associated protein 3.
   
  
 0.618
LOC100684769
IRG-type G domain-containing protein.
   
 
 0.614
ATAD3A
ATPase family AAA domain containing 3A.
      
 0.596
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.