RAP1GAP protein (Canis lupus familiaris) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

RAP1GAP

Rap-GAP domain-containing protein. (462 aa)

Predicted Functional Partners:

RAP1B

0.976

RAP1A

0.956

RALB

0.605

ERAS

0.557

RALGDS

0.552

GFRA2

0.532

APBB1IP

0.528

GPSM1

0.525

GFRA1

0.520

RASGRP4

0.502

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB1IP	RALB	ENSCAFP00000006427	ENSCAFP00000007237	Amyloid beta precursor protein binding family B member 1 interacting protein.	RAS like proto-oncogene B.	0.432
APBB1IP	RAP1A	ENSCAFP00000006427	ENSCAFP00000040927	Amyloid beta precursor protein binding family B member 1 interacting protein.	RAP1A, member of RAS oncogene family.	0.960
APBB1IP	RAP1B	ENSCAFP00000006427	ENSCAFP00000000596	Amyloid beta precursor protein binding family B member 1 interacting protein.	RAP1B, member of RAS oncogene family.	0.961
APBB1IP	RAP1GAP	ENSCAFP00000006427	ENSCAFP00000021878	Amyloid beta precursor protein binding family B member 1 interacting protein.	Rap-GAP domain-containing protein.	0.528
ERAS	RALGDS	ENSCAFP00000023006	ENSCAFP00000057240	ES cell expressed Ras.	Uncharacterized protein.	0.547
ERAS	RAP1GAP	ENSCAFP00000023006	ENSCAFP00000021878	ES cell expressed Ras.	Rap-GAP domain-containing protein.	0.557
GFRA1	GFRA2	ENSCAFP00000034043	ENSCAFP00000037962	GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family.	GDNF family receptor alpha 2.	0.497
GFRA1	RAP1GAP	ENSCAFP00000034043	ENSCAFP00000021878	GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family.	Rap-GAP domain-containing protein.	0.520
GFRA2	GFRA1	ENSCAFP00000037962	ENSCAFP00000034043	GDNF family receptor alpha 2.	GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family.	0.497
GFRA2	RAP1GAP	ENSCAFP00000037962	ENSCAFP00000021878	GDNF family receptor alpha 2.	Rap-GAP domain-containing protein.	0.532
GPSM1	RAP1GAP	ENSCAFP00000057631	ENSCAFP00000021878	G protein signaling modulator 1.	Rap-GAP domain-containing protein.	0.525
RALB	APBB1IP	ENSCAFP00000007237	ENSCAFP00000006427	RAS like proto-oncogene B.	Amyloid beta precursor protein binding family B member 1 interacting protein.	0.432
RALB	RALGDS	ENSCAFP00000007237	ENSCAFP00000057240	RAS like proto-oncogene B.	Uncharacterized protein.	0.971
RALB	RAP1GAP	ENSCAFP00000007237	ENSCAFP00000021878	RAS like proto-oncogene B.	Rap-GAP domain-containing protein.	0.605
RALGDS	ERAS	ENSCAFP00000057240	ENSCAFP00000023006	Uncharacterized protein.	ES cell expressed Ras.	0.547
RALGDS	RALB	ENSCAFP00000057240	ENSCAFP00000007237	Uncharacterized protein.	RAS like proto-oncogene B.	0.971
RALGDS	RAP1A	ENSCAFP00000057240	ENSCAFP00000040927	Uncharacterized protein.	RAP1A, member of RAS oncogene family.	0.947
RALGDS	RAP1B	ENSCAFP00000057240	ENSCAFP00000000596	Uncharacterized protein.	RAP1B, member of RAS oncogene family.	0.967
RALGDS	RAP1GAP	ENSCAFP00000057240	ENSCAFP00000021878	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.552
RAP1A	APBB1IP	ENSCAFP00000040927	ENSCAFP00000006427	RAP1A, member of RAS oncogene family.	Amyloid beta precursor protein binding family B member 1 interacting protein.	0.960

page 1 of 3

Network Stats

number of nodes:

4

number of edges:

3

average node degree:

1.5

avg. local clustering coefficient:

0.75

expected number of edges:

3

PPI enrichment p-value:

0.601

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17809

Leucine-rich repeat, typical subtype, and YD repeat

4 of 43

2.59

4.79

2.07e-07

CL:17869

YD repeat, and Galactose binding lectin domain

3 of 10

3.1

4.39

1.84e-06

CL:17872

GPCR, family 2, latrophilin, and YD repeat

2 of 5

3.22

2.66

0.00037

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02140

Galactose binding lectin domain

3 of 6

3.32

4.69

8.54e-07

PF02354

Latrophilin Cytoplasmic C-terminal region

2 of 2

3.62

2.81

0.00025

PF16489

GPCR-Autoproteolysis INducing (GAIN) domain

2 of 6

3.14

2.4

0.00079

PF00002

7 transmembrane receptor (Secretin family)

2 of 40

2.32

1.31

0.0181

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR043159

D-galactoside/L-rhamnose binding SUEL lectin domain superfamily

3 of 6

3.32

4.31

2.67e-06

IPR003924

GPCR, family 2, latrophilin

2 of 2

3.62

2.42

0.00079

IPR003334

GPCR, family 2, latrophilin, C-terminal

2 of 2

3.62

2.42

0.00079

IPR000922

D-galactoside/L-rhamnose binding SUEL lectin domain

2 of 5

3.22

2.22

0.0014

IPR032471

GAIN domain, N-terminal

2 of 7

3.07

2.11

0.0019

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00284

Olfactomedin-like domains

2 of 9

2.97

2.14

0.0017

SM00303

G-protein-coupled receptor proteolytic site domain

2 of 19

2.64

1.89

0.0033

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