CHD4 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CHD4

Chromodomain helicase DNA binding protein 4. (1984 aa)

Predicted Functional Partners:

HDAC1

0.981

GATAD2A

0.973

HDAC2

0.969

MTA2

0.959

GATAD2B

0.944

MTA1

0.932

IRF1

0.908

RBBP7

0.887

MTA3

0.885

ENSCAFP00000058271

0.884

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHD4	ENSCAFP00000058271	ENSCAFP00000022067	ENSCAFP00000058271	Chromodomain helicase DNA binding protein 4.	WD_REPEATS_REGION domain-containing protein.	0.884
CHD4	GATAD2A	ENSCAFP00000022067	ENSCAFP00000047971	Chromodomain helicase DNA binding protein 4.	GATA zinc finger domain containing 2A.	0.973
CHD4	GATAD2B	ENSCAFP00000022067	ENSCAFP00000025700	Chromodomain helicase DNA binding protein 4.	GATA zinc finger domain containing 2B.	0.944
CHD4	HDAC1	ENSCAFP00000022067	ENSCAFP00000036819	Chromodomain helicase DNA binding protein 4.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.981
CHD4	HDAC2	ENSCAFP00000022067	ENSCAFP00000042408	Chromodomain helicase DNA binding protein 4.	Histone deacetylase 2.	0.969
CHD4	IRF1	ENSCAFP00000022067	ENSCAFP00000001223	Chromodomain helicase DNA binding protein 4.	Interferon regulatory factor 1.	0.908
CHD4	MTA1	ENSCAFP00000022067	ENSCAFP00000027224	Chromodomain helicase DNA binding protein 4.	Metastasis associated 1.	0.932
CHD4	MTA2	ENSCAFP00000022067	ENSCAFP00000023249	Chromodomain helicase DNA binding protein 4.	Metastasis associated 1 family member 2.	0.959
CHD4	MTA3	ENSCAFP00000022067	ENSCAFP00000009773	Chromodomain helicase DNA binding protein 4.	Metastasis associated 1 family member 3.	0.885
CHD4	RBBP7	ENSCAFP00000022067	ENSCAFP00000018764	Chromodomain helicase DNA binding protein 4.	RB binding protein 7, chromatin remodeling factor.	0.887
ENSCAFP00000058271	CHD4	ENSCAFP00000058271	ENSCAFP00000022067	WD_REPEATS_REGION domain-containing protein.	Chromodomain helicase DNA binding protein 4.	0.884
ENSCAFP00000058271	GATAD2A	ENSCAFP00000058271	ENSCAFP00000047971	WD_REPEATS_REGION domain-containing protein.	GATA zinc finger domain containing 2A.	0.867
ENSCAFP00000058271	GATAD2B	ENSCAFP00000058271	ENSCAFP00000025700	WD_REPEATS_REGION domain-containing protein.	GATA zinc finger domain containing 2B.	0.853
ENSCAFP00000058271	HDAC1	ENSCAFP00000058271	ENSCAFP00000036819	WD_REPEATS_REGION domain-containing protein.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.869
ENSCAFP00000058271	HDAC2	ENSCAFP00000058271	ENSCAFP00000042408	WD_REPEATS_REGION domain-containing protein.	Histone deacetylase 2.	0.869
ENSCAFP00000058271	MTA1	ENSCAFP00000058271	ENSCAFP00000027224	WD_REPEATS_REGION domain-containing protein.	Metastasis associated 1.	0.883
ENSCAFP00000058271	MTA2	ENSCAFP00000058271	ENSCAFP00000023249	WD_REPEATS_REGION domain-containing protein.	Metastasis associated 1 family member 2.	0.949
ENSCAFP00000058271	MTA3	ENSCAFP00000058271	ENSCAFP00000009773	WD_REPEATS_REGION domain-containing protein.	Metastasis associated 1 family member 3.	0.814
ENSCAFP00000058271	RBBP7	ENSCAFP00000058271	ENSCAFP00000018764	WD_REPEATS_REGION domain-containing protein.	RB binding protein 7, chromatin remodeling factor.	0.930
GATAD2A	CHD4	ENSCAFP00000047971	ENSCAFP00000022067	GATA zinc finger domain containing 2A.	Chromodomain helicase DNA binding protein 4.	0.973