node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS13 | F8 | ENSCAFP00000029268 | ENSCAFP00000029035 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | 0.596 |
ADAMTS13 | SELP | ENSCAFP00000029268 | ENSCAFP00000033641 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Uncharacterized protein. | 0.470 |
ADAMTS13 | VWF | ENSCAFP00000029268 | ENSCAFP00000053390 | ADAM metallopeptidase with thrombospondin type 1 motif 13. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). | 0.928 |
CD34 | ITGA2B | ENSCAFP00000017250 | ENSCAFP00000053835 | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. | 0.477 |
CD34 | ITGAV | ENSCAFP00000017250 | ENSCAFP00000050990 | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.475 |
CD34 | ITGB3 | ENSCAFP00000017250 | ENSCAFP00000032511 | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). | Integrin beta; Belongs to the integrin beta chain family. | 0.430 |
CD34 | PECAM1 | ENSCAFP00000017250 | ENSCAFP00000032086 | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). | Platelet and endothelial cell adhesion molecule 1. | 0.856 |
CD34 | SELP | ENSCAFP00000017250 | ENSCAFP00000033641 | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). | Uncharacterized protein. | 0.472 |
CD34 | VWF | ENSCAFP00000017250 | ENSCAFP00000053390 | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). | 0.933 |
CLDN5 | PECAM1 | ENSCAFP00000045788 | ENSCAFP00000032086 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Platelet and endothelial cell adhesion molecule 1. | 0.636 |
CLDN5 | VWF | ENSCAFP00000045788 | ENSCAFP00000053390 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). | 0.856 |
F8 | ADAMTS13 | ENSCAFP00000029035 | ENSCAFP00000029268 | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | ADAM metallopeptidase with thrombospondin type 1 motif 13. | 0.596 |
F8 | VWF | ENSCAFP00000029035 | ENSCAFP00000053390 | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). | 0.987 |
GP1BB | ITGA2B | ENSCAFP00000036500 | ENSCAFP00000053835 | Glycoprotein Ib platelet subunit beta. | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. | 0.561 |
GP1BB | ITGB3 | ENSCAFP00000036500 | ENSCAFP00000032511 | Glycoprotein Ib platelet subunit beta. | Integrin beta; Belongs to the integrin beta chain family. | 0.421 |
GP1BB | VWF | ENSCAFP00000036500 | ENSCAFP00000053390 | Glycoprotein Ib platelet subunit beta. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). | 0.959 |
ITGA2B | CD34 | ENSCAFP00000053835 | ENSCAFP00000017250 | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). | 0.477 |
ITGA2B | GP1BB | ENSCAFP00000053835 | ENSCAFP00000036500 | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. | Glycoprotein Ib platelet subunit beta. | 0.561 |
ITGA2B | ITGAV | ENSCAFP00000053835 | ENSCAFP00000050990 | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. | Integrin subunit alpha V; Belongs to the integrin alpha chain family. | 0.912 |
ITGA2B | ITGB3 | ENSCAFP00000053835 | ENSCAFP00000032511 | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. | Integrin beta; Belongs to the integrin beta chain family. | 0.998 |