STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (455 aa)    
Predicted Functional Partners:
MAP2K4
Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
   
 
 0.915
MAP2K6
Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.
    
 0.904
MAP2K3
Mitogen-activated protein kinase kinase 3.
    
 0.904
SMAD2
Mothers against decapentaplegic homolog.
   
 0.768
SMAD3
Mothers against decapentaplegic homolog.
   
 0.732
SMAD4
Mothers against decapentaplegic homolog.
   
 0.692
ZDHHC1
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
   
 
 0.691
PPM1B
Protein phosphatase, Mg2+/Mn2+ dependent 1B.
  
 
0.676
PPM1N
Protein phosphatase, Mg2+/Mn2+ dependent 1N (putative).
  
  
0.658
SETD2
SET domain containing 2, histone lysine methyltransferase.
   
 
 0.564
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.