Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDC42-2 | PIK3CA | ENSCAFP00000060180 | ENSCAFP00000048355 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.939 |
| CDC42-2 | PIK3CB | ENSCAFP00000060180 | ENSCAFP00000011245 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.972 |
| CDC42-2 | PIK3R1 | ENSCAFP00000060180 | ENSCAFP00000011322 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Phosphoinositide-3-kinase regulatory subunit 1. | 0.945 |
| CDC42-2 | PIK3R2 | ENSCAFP00000060180 | ENSCAFP00000022072 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Uncharacterized protein. | 0.923 |
| CDC42-2 | PTEN | ENSCAFP00000060180 | ENSCAFP00000045099 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.947 |
| CDC42-2 | PTK2 | ENSCAFP00000060180 | ENSCAFP00000051882 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.479 |
| CDC42-2 | ROCK1 | ENSCAFP00000060180 | ENSCAFP00000050426 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.647 |
| CHUK | PIK3R1 | ENSCAFP00000014093 | ENSCAFP00000011322 | Component of inhibitor of nuclear factor kappa B kinase complex. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.443 |
| CHUK | PIK3R2 | ENSCAFP00000014093 | ENSCAFP00000022072 | Component of inhibitor of nuclear factor kappa B kinase complex. | Uncharacterized protein. | 0.417 |
| CHUK | PTEN | ENSCAFP00000014093 | ENSCAFP00000045099 | Component of inhibitor of nuclear factor kappa B kinase complex. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.942 |
| INPP4B | PIK3CA | ENSCAFP00000005396 | ENSCAFP00000048355 | Inositol polyphosphate-4-phosphatase type II B. | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | 0.563 |
| INPP4B | PIK3R1 | ENSCAFP00000005396 | ENSCAFP00000011322 | Inositol polyphosphate-4-phosphatase type II B. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.927 |
| INPP4B | PIK3R2 | ENSCAFP00000005396 | ENSCAFP00000022072 | Inositol polyphosphate-4-phosphatase type II B. | Uncharacterized protein. | 0.917 |
| INPP4B | PTEN | ENSCAFP00000005396 | ENSCAFP00000045099 | Inositol polyphosphate-4-phosphatase type II B. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.955 |
| PIK3CA | CDC42-2 | ENSCAFP00000048355 | ENSCAFP00000060180 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] | 0.939 |
| PIK3CA | INPP4B | ENSCAFP00000048355 | ENSCAFP00000005396 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Inositol polyphosphate-4-phosphatase type II B. | 0.563 |
| PIK3CA | PIK3CB | ENSCAFP00000048355 | ENSCAFP00000011245 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. | 0.948 |
| PIK3CA | PIK3R1 | ENSCAFP00000048355 | ENSCAFP00000011322 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Phosphoinositide-3-kinase regulatory subunit 1. | 0.999 |
| PIK3CA | PIK3R2 | ENSCAFP00000048355 | ENSCAFP00000022072 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Uncharacterized protein. | 0.992 |
| PIK3CA | PTEN | ENSCAFP00000048355 | ENSCAFP00000045099 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.988 |
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