STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FASFas cell surface death receptor. (734 aa)    
Predicted Functional Partners:
FASLG
Tumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family.
    
 0.992
DAXX
Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...]
   
 0.980
TNFRSF1A
TNF receptor superfamily member 1A.
   
0.960
CASP8
Caspase 8; Belongs to the peptidase C14A family.
   
 0.953
TRADD
TNFRSF1A associated via death domain.
   
 0.949
FAF1
Fas associated factor 1.
    
 0.944
CFLAR
CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.
   
 
 0.746
RIPK1
Receptor interacting serine/threonine kinase 1.
   
 0.736
ERN1
Endoplasmic reticulum to nucleus signaling 1.
   
 
 0.736
LOC100687054
Ig-like domain-containing protein.
    
 
 0.720
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.