STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DHX58DExH-box helicase 58. (678 aa)    
Predicted Functional Partners:
DDX58
DExD/H-box helicase 58.
   
0.975
USP18
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
   
  
 0.894
ISG15
ISG15 ubiquitin like modifier.
   
 
 0.820
DDX60
DExD/H-box helicase 60.
   
 
 0.783
RSAD2
Radical S-adenosyl methionine domain containing 2.
   
  
 0.778
RTP4
Receptor transporter protein 4.
   
  
 0.772
F6Y518_CANLF
IRF-3 domain-containing protein.
   
 
 0.766
IFI44
Interferon induced protein 44.
   
 
 0.751
WRN
WRN RecQ like helicase.
   
 
 0.731
EIF2AK2
Eukaryotic translation initiation factor 2-alpha kinase 2.
   
 
 0.704
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.