node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD63 | RAB27A | ENSCAFP00000041004 | ENSCAFP00000023411 | Tetraspanin. | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.833 |
CD63 | RAB27B | ENSCAFP00000041004 | ENSCAFP00000000213 | Tetraspanin. | RAB27B, member RAS oncogene family. | 0.888 |
DCT | MYO5A | ENSCAFP00000007942 | ENSCAFP00000050462 | Uncharacterized protein. | Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.607 |
DCT | RAB27A | ENSCAFP00000007942 | ENSCAFP00000023411 | Uncharacterized protein. | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.729 |
DCT | TYR | ENSCAFP00000007942 | ENSCAFP00000006504 | Uncharacterized protein. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family. | 0.760 |
MYO5A | DCT | ENSCAFP00000050462 | ENSCAFP00000007942 | Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Uncharacterized protein. | 0.607 |
MYO5A | RAB27A | ENSCAFP00000050462 | ENSCAFP00000023411 | Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.935 |
MYO5A | SYTL1 | ENSCAFP00000050462 | ENSCAFP00000063870 | Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Synaptotagmin like 1. | 0.449 |
MYO5A | SYTL3 | ENSCAFP00000050462 | ENSCAFP00000000929 | Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Synaptotagmin like 3. | 0.469 |
MYO5A | SYTL5 | ENSCAFP00000050462 | ENSCAFP00000020573 | Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Synaptotagmin like 5. | 0.467 |
MYO5A | TYR | ENSCAFP00000050462 | ENSCAFP00000006504 | Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family. | 0.654 |
RAB27A | CD63 | ENSCAFP00000023411 | ENSCAFP00000041004 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Tetraspanin. | 0.833 |
RAB27A | DCT | ENSCAFP00000023411 | ENSCAFP00000007942 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Uncharacterized protein. | 0.729 |
RAB27A | MYO5A | ENSCAFP00000023411 | ENSCAFP00000050462 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Myosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | 0.935 |
RAB27A | RAB27B | ENSCAFP00000023411 | ENSCAFP00000000213 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | RAB27B, member RAS oncogene family. | 0.807 |
RAB27A | SYTL1 | ENSCAFP00000023411 | ENSCAFP00000063870 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Synaptotagmin like 1. | 0.703 |
RAB27A | SYTL2 | ENSCAFP00000023411 | ENSCAFP00000052959 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Synaptotagmin like 2. | 0.813 |
RAB27A | SYTL3 | ENSCAFP00000023411 | ENSCAFP00000000929 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Synaptotagmin like 3. | 0.776 |
RAB27A | SYTL4 | ENSCAFP00000023411 | ENSCAFP00000025824 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Synaptotagmin like 4. | 0.732 |
RAB27A | SYTL5 | ENSCAFP00000023411 | ENSCAFP00000020573 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Synaptotagmin like 5. | 0.719 |