STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NEDD4NEDD4 E3 ubiquitin protein ligase. (1323 aa)    
Predicted Functional Partners:
NDFIP2
Nedd4 family interacting protein 2.
    
 
 0.996
ARRDC3
Arrestin domain containing 3.
    
 
 0.990
NDFIP1
Nedd4 family interacting protein 1.
    
 
 0.977
SCNN1B
Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensit [...]
    
 
 0.950
ISG15
ISG15 ubiquitin like modifier.
    
 0.943
NEDD4L
NEDD4 like E3 ubiquitin protein ligase.
  
 
0.925
GRB10
Growth factor receptor bound protein 10.
    
 
 0.914
DLG3-2
SH3 domain-containing protein.
   
 0.913
LYN
Tyrosine-protein kinase.
    
 0.907
SYK
Tyrosine-protein kinase.
    
 0.906
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.