STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKAP8A-kinase anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression. Required for cell cycle G2/M transition and histone deacetyla [...] (682 aa)    
Predicted Functional Partners:
AKAP10
A-kinase anchoring protein 10.
   
  
 0.637
AKAP7
A-kinase anchoring protein 7.
      
 0.625
PAK6
Non-specific serine/threonine protein kinase.
      
 0.607
ZDHHC19
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
    
 
 0.578
IGF2BP1
Insulin like growth factor 2 mRNA binding protein 1.
   
  
 0.578
ANKRD55
Ankyrin repeat domain 55.
    
 
 0.570
CLHC1
Clathrin heavy chain linker domain containing 1.
   
  
 0.570
LUZP2
Leucine zipper protein 2.
      
 0.564
MAP3K8
Mitogen-activated protein kinase kinase kinase 8.
   
 
 0.552
STK25
Protein kinase domain-containing protein.
    
 
 0.549
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.