STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOTCH3Notch receptor 3. (2148 aa)    
Predicted Functional Partners:
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.993
JAG1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
0.989
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.982
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
0.982
MAML1
Mastermind like transcriptional coactivator 1.
   
 0.962
DVL3
Dishevelled segment polarity protein 3.
    
 0.957
NOTCH1
Notch receptor 1.
  
0.955
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase.
   
 0.951
NUMB
NUMB endocytic adaptor protein.
   
 0.950
MAML3
Mastermind like transcriptional coactivator 3.
   
 0.944
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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