STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLF3Kruppel like factor 3. (345 aa)    
Predicted Functional Partners:
TESC
Tescalcin.
    
 
 0.695
CNKSR2
Connector enhancer of kinase suppressor of Ras 2.
      
 0.636
TMEM156
Transmembrane protein 156.
      
 0.630
FHL3
Four and a half LIM domains 3.
   
 
 0.626
SIX4
SIX homeobox 4.
   
 
 0.574
CTBP1
C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
   
 
 0.569
UBE2K
Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.558
LIAS
Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
      
 0.557
KLHL5
Kelch like family member 5.
   
 
 0.555
ATF7
Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters.
   
 
 0.554
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.