STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACAP1ArfGAP with coiled-coil, ankyrin repeat and PH domains 1. (725 aa)    
Predicted Functional Partners:
AGFG2
ArfGAP with FG repeats 2.
      
 0.842
HPX
Amyloid beta precursor protein binding family B member 1.
    
 
 0.785
RAB35
RAB35, member RAS oncogene family.
    
 
 0.709
ARF6
ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.
    
 
 0.664
APPL1
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.
   
 
0.636
APPL2
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.
   
 
 0.600
MCTP1
Multiple C2 and transmembrane domain containing 1.
      
 0.562
TTC39B
Tetratricopeptide repeat domain 39B.
      
 0.561
MAP4K1
Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
   
  
 0.553
SNX17
Sorting nexin 17.
    
 
 0.553
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.