GRB7 protein (Canis lupus familiaris) - STRING interaction network

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Score

GRB7

Growth factor receptor bound protein 7. (553 aa)

Predicted Functional Partners:

ERBB2

0.904

PDGFRB

0.812

TEK

0.731

UBAP2L

0.718

ERBB3

0.701

RND1

0.642

KIT

0.631

ERBB4

0.631

GRB2

0.623

RET

0.596

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERBB2	ERBB3	ENSCAFP00000024079	ENSCAFP00000000139	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Erb-b2 receptor tyrosine kinase 3.	0.998
ERBB2	ERBB4	ENSCAFP00000024079	ENSCAFP00000048210	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Receptor protein-tyrosine kinase.	0.991
ERBB2	GRB2	ENSCAFP00000024079	ENSCAFP00000049390	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Growth factor receptor bound protein 2.	0.991
ERBB2	GRB7	ENSCAFP00000024079	ENSCAFP00000024052	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Growth factor receptor bound protein 7.	0.904
ERBB2	PDGFRB	ENSCAFP00000024079	ENSCAFP00000000714	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...]	0.557
ERBB2	RND1	ENSCAFP00000024079	ENSCAFP00000012955	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	Rho family GTPase 1.	0.612
ERBB3	ERBB2	ENSCAFP00000000139	ENSCAFP00000024079	Erb-b2 receptor tyrosine kinase 3.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.998
ERBB3	ERBB4	ENSCAFP00000000139	ENSCAFP00000048210	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.970
ERBB3	GRB2	ENSCAFP00000000139	ENSCAFP00000049390	Erb-b2 receptor tyrosine kinase 3.	Growth factor receptor bound protein 2.	0.977
ERBB3	GRB7	ENSCAFP00000000139	ENSCAFP00000024052	Erb-b2 receptor tyrosine kinase 3.	Growth factor receptor bound protein 7.	0.701
ERBB3	PDGFRB	ENSCAFP00000000139	ENSCAFP00000000714	Erb-b2 receptor tyrosine kinase 3.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...]	0.433
ERBB4	ERBB2	ENSCAFP00000048210	ENSCAFP00000024079	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.991
ERBB4	ERBB3	ENSCAFP00000048210	ENSCAFP00000000139	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.970
ERBB4	GRB2	ENSCAFP00000048210	ENSCAFP00000049390	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 2.	0.981
ERBB4	GRB7	ENSCAFP00000048210	ENSCAFP00000024052	Receptor protein-tyrosine kinase.	Growth factor receptor bound protein 7.	0.631
ERBB4	PDGFRB	ENSCAFP00000048210	ENSCAFP00000000714	Receptor protein-tyrosine kinase.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...]	0.402
GRB2	ERBB2	ENSCAFP00000049390	ENSCAFP00000024079	Growth factor receptor bound protein 2.	Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]	0.991
GRB2	ERBB3	ENSCAFP00000049390	ENSCAFP00000000139	Growth factor receptor bound protein 2.	Erb-b2 receptor tyrosine kinase 3.	0.977
GRB2	ERBB4	ENSCAFP00000049390	ENSCAFP00000048210	Growth factor receptor bound protein 2.	Receptor protein-tyrosine kinase.	0.981
GRB2	GRB7	ENSCAFP00000049390	ENSCAFP00000024052	Growth factor receptor bound protein 2.	Growth factor receptor bound protein 7.	0.623