STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZBTB4Zinc finger and BTB domain containing 4. (1079 aa)    
Predicted Functional Partners:
HES7
Hes family bHLH transcription factor 7.
   
  
 0.791
TMEM141
Transmembrane protein 141.
      
 0.771
GANAB
Glucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family.
   
 
 0.656
HIPK2
Homeodomain interacting protein kinase 2.
   
 
 0.639
POLN
DNA polymerase nu.
   
  
 0.630
TTYH3
Protein tweety homolog; Probable chloride channel; Belongs to the tweety family.
      
 0.606
ZHX2
Zinc fingers and homeoboxes 2.
   
 
 0.601
HSPA14
Heat shock protein family A (Hsp70) member 14; Belongs to the heat shock protein 70 family.
   
 
 0.560
TNK1
Tyrosine kinase non receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 
 0.559
EIF3F
Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]
   
 
 0.553
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.