node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRE2 | APOM | ENSCAFP00000024120 | ENSCAFP00000000845 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | Apolipoprotein M. | 0.490 |
ADGRE2 | CA6 | ENSCAFP00000024120 | ENSCAFP00000029168 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown (By similarity); Belongs to the alpha-carbonic anhydrase family. | 0.429 |
ADGRE2 | CD4 | ENSCAFP00000024120 | ENSCAFP00000063394 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | 0.519 |
ADGRE2 | CD5 | ENSCAFP00000024120 | ENSCAFP00000024058 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | CD5 molecule. | 0.445 |
ADGRE2 | CD55 | ENSCAFP00000024120 | ENSCAFP00000058831 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | CD55 molecule. | 0.513 |
ADGRE2 | CD79A | ENSCAFP00000024120 | ENSCAFP00000053606 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | B-cell antigen receptor complex-associated protein alpha chain; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts wit [...] | 0.575 |
ADGRE2 | CNTN4 | ENSCAFP00000024120 | ENSCAFP00000009030 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | Contactin 4. | 0.454 |
ADGRE2 | FOXP3 | ENSCAFP00000024120 | ENSCAFP00000023435 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | Forkhead box P3. | 0.472 |
ADGRE2 | NCR3 | ENSCAFP00000024120 | ENSCAFP00000042663 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | Natural cytotoxicity triggering receptor 3. | 0.453 |
ADGRE2 | TLR6 | ENSCAFP00000024120 | ENSCAFP00000023836 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | Toll like receptor 6; Belongs to the Toll-like receptor family. | 0.418 |
APOM | ADGRE2 | ENSCAFP00000000845 | ENSCAFP00000024120 | Apolipoprotein M. | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | 0.490 |
APOM | CA6 | ENSCAFP00000000845 | ENSCAFP00000029168 | Apolipoprotein M. | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown (By similarity); Belongs to the alpha-carbonic anhydrase family. | 0.458 |
APOM | CNTN4 | ENSCAFP00000000845 | ENSCAFP00000009030 | Apolipoprotein M. | Contactin 4. | 0.450 |
CA6 | ADGRE2 | ENSCAFP00000029168 | ENSCAFP00000024120 | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown (By similarity); Belongs to the alpha-carbonic anhydrase family. | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | 0.429 |
CA6 | APOM | ENSCAFP00000029168 | ENSCAFP00000000845 | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown (By similarity); Belongs to the alpha-carbonic anhydrase family. | Apolipoprotein M. | 0.458 |
CA6 | CNTN4 | ENSCAFP00000029168 | ENSCAFP00000009030 | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown (By similarity); Belongs to the alpha-carbonic anhydrase family. | Contactin 4. | 0.417 |
CD4 | ADGRE2 | ENSCAFP00000063394 | ENSCAFP00000024120 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. | 0.519 |
CD4 | CD5 | ENSCAFP00000063394 | ENSCAFP00000024058 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | CD5 molecule. | 0.920 |
CD4 | CD55 | ENSCAFP00000063394 | ENSCAFP00000058831 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | CD55 molecule. | 0.451 |
CD4 | CD79A | ENSCAFP00000063394 | ENSCAFP00000053606 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] | B-cell antigen receptor complex-associated protein alpha chain; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts wit [...] | 0.692 |