STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANGPTL7Angiopoietin like 7. (344 aa)    
Predicted Functional Partners:
CILP
Poly [ADP-ribose] polymerase.
   
 
 0.709
MYOC
Myocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...]
   
  
 0.655
ITGBL1
Integrin subunit beta like 1.
    
 
 0.643
ZBED9
Zinc finger BED-type containing 9.
    
 
 0.609
TRIM69
Tripartite motif containing 69.
    
 
 0.491
FAM180A
Family with sequence similarity 180 member A.
      
 0.491
TEK
TEK receptor tyrosine kinase.
   
 
 0.485
TIE1
Tyrosine kinase with immunoglobulin like and EGF like domains 1.
   
 
 0.476
SENP1
SUMO specific peptidase 1.
      
 0.475
C21H11orf58
SMAP domain-containing protein.
      
 0.468
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.