NPC2 protein (Canis lupus familiaris) - STRING interaction network

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Score

NPC2

NPC intracellular cholesterol transporter 2. (248 aa)

Predicted Functional Partners:

NPC1

0.994

SCAP

0.626

STARD3

0.615

LCNL1

0.606

CRISP2

0.591

GM2A

0.583

SLC9A3R2

0.551

SMPD1

0.545

LAMP2

0.513

FTL

0.499

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRISP2	LCNL1	ENSCAFP00000044670	ENSCAFP00000028877	Cysteine rich secretory protein 2; Belongs to the CRISP family.	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	0.810
CRISP2	NPC2	ENSCAFP00000044670	ENSCAFP00000055843	Cysteine rich secretory protein 2; Belongs to the CRISP family.	NPC intracellular cholesterol transporter 2.	0.591
FTL	NPC2	ENSCAFP00000005761	ENSCAFP00000055843	Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family.	NPC intracellular cholesterol transporter 2.	0.499
GM2A	NPC2	ENSCAFP00000026432	ENSCAFP00000055843	GM2 ganglioside activator.	NPC intracellular cholesterol transporter 2.	0.583
LAMP2	NPC1	ENSCAFP00000043773	ENSCAFP00000057176	Lysosomal associated membrane protein 2.	NPC intracellular cholesterol transporter 1.	0.475
LAMP2	NPC2	ENSCAFP00000043773	ENSCAFP00000055843	Lysosomal associated membrane protein 2.	NPC intracellular cholesterol transporter 2.	0.513
LCNL1	CRISP2	ENSCAFP00000028877	ENSCAFP00000044670	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	Cysteine rich secretory protein 2; Belongs to the CRISP family.	0.810
LCNL1	NPC2	ENSCAFP00000028877	ENSCAFP00000055843	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	NPC intracellular cholesterol transporter 2.	0.606
NPC1	LAMP2	ENSCAFP00000057176	ENSCAFP00000043773	NPC intracellular cholesterol transporter 1.	Lysosomal associated membrane protein 2.	0.475
NPC1	NPC2	ENSCAFP00000057176	ENSCAFP00000055843	NPC intracellular cholesterol transporter 1.	NPC intracellular cholesterol transporter 2.	0.994
NPC1	SMPD1	ENSCAFP00000057176	ENSCAFP00000009604	NPC intracellular cholesterol transporter 1.	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.	0.537
NPC1	STARD3	ENSCAFP00000057176	ENSCAFP00000024111	NPC intracellular cholesterol transporter 1.	StAR related lipid transfer domain containing 3.	0.713
NPC2	CRISP2	ENSCAFP00000055843	ENSCAFP00000044670	NPC intracellular cholesterol transporter 2.	Cysteine rich secretory protein 2; Belongs to the CRISP family.	0.591
NPC2	FTL	ENSCAFP00000055843	ENSCAFP00000005761	NPC intracellular cholesterol transporter 2.	Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity); Belongs to the ferritin family.	0.499
NPC2	GM2A	ENSCAFP00000055843	ENSCAFP00000026432	NPC intracellular cholesterol transporter 2.	GM2 ganglioside activator.	0.583
NPC2	LAMP2	ENSCAFP00000055843	ENSCAFP00000043773	NPC intracellular cholesterol transporter 2.	Lysosomal associated membrane protein 2.	0.513
NPC2	LCNL1	ENSCAFP00000055843	ENSCAFP00000028877	NPC intracellular cholesterol transporter 2.	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family.	0.606
NPC2	NPC1	ENSCAFP00000055843	ENSCAFP00000057176	NPC intracellular cholesterol transporter 2.	NPC intracellular cholesterol transporter 1.	0.994
NPC2	SCAP	ENSCAFP00000055843	ENSCAFP00000019461	NPC intracellular cholesterol transporter 2.	SREBF chaperone.	0.626
NPC2	SLC9A3R2	ENSCAFP00000055843	ENSCAFP00000061476	NPC intracellular cholesterol transporter 2.	Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.	0.551