STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAPK3Mitogen-activated protein kinase. (283 aa)    
Predicted Functional Partners:
PTPN7
Protein tyrosine phosphatase non-receptor type 7.
    
 0.906
PEA15
Proliferation and apoptosis adaptor protein 15.
    
 0.871
FOS
Fos proto-oncogene, AP-1 transcription factor subunit.
    
 0.853
RPS6KA1
Non-specific serine/threonine protein kinase.
   
0.821
CEBPB
CCAAT/enhancer-binding protein.
    
 0.811
MAPK1
Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
  
  
0.803
HSF1
Heat shock transcription factor 1.
   
 0.797
RPS6KA5
Ribosomal protein S6 kinase.
   
0.790
RAF1
Raf-1 proto-oncogene, serine/threonine kinase.
   
 0.789
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
   
 0.771
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.