node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLN3 | CLN5 | ENSCAFP00000025242 | ENSCAFP00000007554 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | 0.934 |
CLN3 | CLN6 | ENSCAFP00000025242 | ENSCAFP00000025751 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Ceroid-lipofuscinosis neuronal protein 6 homolog. | 0.920 |
CLN3 | CLN8 | ENSCAFP00000025242 | ENSCAFP00000024048 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. | 0.908 |
CLN3 | CTSD | ENSCAFP00000025242 | ENSCAFP00000014791 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.830 |
CLN3 | CTSF | ENSCAFP00000025242 | ENSCAFP00000018312 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Cathepsin F; Belongs to the peptidase C1 family. | 0.825 |
CLN3 | HMGCL | ENSCAFP00000025242 | ENSCAFP00000019305 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | 3-hydroxy-3-methylglutaryl-CoA lyase. | 0.894 |
CLN3 | HMGCLL1 | ENSCAFP00000025242 | ENSCAFP00000055926 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. | 0.819 |
CLN3 | MFSD8 | ENSCAFP00000025242 | ENSCAFP00000005754 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Major facilitator superfamily domain containing 8. | 0.915 |
CLN3 | PPT1 | ENSCAFP00000025242 | ENSCAFP00000049082 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Palmitoyl-protein thioesterase 1. | 0.822 |
CLN3 | TPP1 | ENSCAFP00000025242 | ENSCAFP00000009732 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). | 0.887 |
CLN5 | CLN3 | ENSCAFP00000007554 | ENSCAFP00000025242 | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | 0.934 |
CLN5 | CLN6 | ENSCAFP00000007554 | ENSCAFP00000025751 | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Ceroid-lipofuscinosis neuronal protein 6 homolog. | 0.942 |
CLN5 | CLN8 | ENSCAFP00000007554 | ENSCAFP00000024048 | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death. | 0.920 |
CLN5 | CTSD | ENSCAFP00000007554 | ENSCAFP00000014791 | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family. | 0.865 |
CLN5 | CTSF | ENSCAFP00000007554 | ENSCAFP00000018312 | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Cathepsin F; Belongs to the peptidase C1 family. | 0.751 |
CLN5 | MFSD8 | ENSCAFP00000007554 | ENSCAFP00000005754 | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Major facilitator superfamily domain containing 8. | 0.902 |
CLN5 | PPT1 | ENSCAFP00000007554 | ENSCAFP00000049082 | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Palmitoyl-protein thioesterase 1. | 0.892 |
CLN5 | TPP1 | ENSCAFP00000007554 | ENSCAFP00000009732 | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). | 0.846 |
CLN6 | CLN3 | ENSCAFP00000025751 | ENSCAFP00000025242 | Ceroid-lipofuscinosis neuronal protein 6 homolog. | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. | 0.920 |
CLN6 | CLN5 | ENSCAFP00000025751 | ENSCAFP00000007554 | Ceroid-lipofuscinosis neuronal protein 6 homolog. | Ceroid-lipofuscinosis neuronal protein 5, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family. | 0.942 |