STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHRNB2Cholinergic receptor nicotinic beta 2 subunit. (500 aa)    
Predicted Functional Partners:
CHRNA4
Cholinergic receptor nicotinic alpha 4 subunit.
  
0.966
JAK2
Janus kinase 2.
    
  0.901
LYNX1
UPAR/Ly6 domain-containing protein.
     
 0.901
CHRNA5
Cholinergic receptor nicotinic alpha 5 subunit.
  
0.859
CHRNA3
Cholinergic receptor nicotinic alpha 3 subunit.
  
 
0.839
CHRNA1
Cholinergic receptor nicotinic alpha 1 subunit.
  
0.763
CHRNA2
Cholinergic receptor nicotinic alpha 2 subunit.
  
0.736
CHRNA7
Uncharacterized protein.
  
0.670
NMUR2
Neuromedin U receptor 2; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.601
CACNG2
Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
   
  
 0.578
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.