LAT protein (Canis lupus familiaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD3E	GRAP2	ENSCAFP00000052947	ENSCAFP00000065984	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	GRB2 related adaptor protein 2.	0.628
CD3E	LAT	ENSCAFP00000052947	ENSCAFP00000025545	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Linker for activation of T cells.	0.997
CD3E	LCP2	ENSCAFP00000052947	ENSCAFP00000040724	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Lymphocyte cytosolic protein 2.	0.714
CD3E	PIK3R1	ENSCAFP00000052947	ENSCAFP00000011322	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Phosphoinositide-3-kinase regulatory subunit 1.	0.589
CD3E	PLCG1	ENSCAFP00000052947	ENSCAFP00000046841	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.513
CD3E	SYK	ENSCAFP00000052947	ENSCAFP00000054848	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.981
CD3E	ZAP70	ENSCAFP00000052947	ENSCAFP00000047083	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein kinase.	0.998
GRAP2	CD3E	ENSCAFP00000065984	ENSCAFP00000052947	GRB2 related adaptor protein 2.	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.628
GRAP2	GRB2	ENSCAFP00000065984	ENSCAFP00000049390	GRB2 related adaptor protein 2.	Growth factor receptor bound protein 2.	0.685
GRAP2	LAT	ENSCAFP00000065984	ENSCAFP00000025545	GRB2 related adaptor protein 2.	Linker for activation of T cells.	0.997
GRAP2	LCP2	ENSCAFP00000065984	ENSCAFP00000040724	GRB2 related adaptor protein 2.	Lymphocyte cytosolic protein 2.	0.999
GRAP2	PIK3R1	ENSCAFP00000065984	ENSCAFP00000011322	GRB2 related adaptor protein 2.	Phosphoinositide-3-kinase regulatory subunit 1.	0.688
GRAP2	PIK3R2	ENSCAFP00000065984	ENSCAFP00000022072	GRB2 related adaptor protein 2.	Uncharacterized protein.	0.651
GRAP2	PLCG1	ENSCAFP00000065984	ENSCAFP00000046841	GRB2 related adaptor protein 2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.866
GRAP2	PLCG2	ENSCAFP00000065984	ENSCAFP00000029622	GRB2 related adaptor protein 2.	Phosphoinositide phospholipase C.	0.806
GRAP2	SYK	ENSCAFP00000065984	ENSCAFP00000054848	GRB2 related adaptor protein 2.	Tyrosine-protein kinase.	0.715
GRAP2	ZAP70	ENSCAFP00000065984	ENSCAFP00000047083	GRB2 related adaptor protein 2.	Tyrosine-protein kinase.	0.814
GRB2	GRAP2	ENSCAFP00000049390	ENSCAFP00000065984	Growth factor receptor bound protein 2.	GRB2 related adaptor protein 2.	0.685
GRB2	LAT	ENSCAFP00000049390	ENSCAFP00000025545	Growth factor receptor bound protein 2.	Linker for activation of T cells.	0.997
GRB2	LCP2	ENSCAFP00000049390	ENSCAFP00000040724	Growth factor receptor bound protein 2.	Lymphocyte cytosolic protein 2.	0.998