STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NAP1L3Nucleosome assembly protein 1 like 3; Belongs to the nucleosome assembly protein (NAP) family. (473 aa)    
Predicted Functional Partners:
HERC3
HECT and RLD domain containing E3 ubiquitin protein ligase 3.
   
  
 0.677
COMMD1
COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF- kappa-B activity. Involved in the regulation of membrane expression and ubiquiti [...]
   
  
 0.512
H2AFZ
Histone H2A; Belongs to the histone H2A family.
   
 
 0.503
J9NWQ8_CANLF
Histone H2A; Belongs to the histone H2A family.
   
 
 0.503
H2AZ2
Histone H2A; Belongs to the histone H2A family.
   
 
 0.503
PNPLA4
Patatin like phospholipase domain containing 4.
   
 
 0.500
SMCO4
Single-pass membrane protein with coiled-coil domains 4.
      
 0.495
TM6SF1
Transmembrane 6 superfamily member 1.
      
 0.493
LONRF1
LON peptidase N-terminal domain and ring finger 1.
      
 0.463
DNAJB3
J domain-containing protein.
    
 
 0.442
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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