SYTL4 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SYTL4

Synaptotagmin like 4. (671 aa)

Predicted Functional Partners:

RAB27B

0.830

RAB27A

0.732

STXBP2

0.602

PDZD11

0.567

RAB8A

0.533

RAB8B

0.533

KCNG1

0.530

OCIAD2

0.522

SH3BGRL2

0.516

STARD10

0.514

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KCNG1	SYTL4	ENSCAFP00000016996	ENSCAFP00000025824	Potassium voltage-gated channel modifier subfamily G member 1; Belongs to the potassium channel family.	Synaptotagmin like 4.	0.530
OCIAD2	SYTL4	ENSCAFP00000052996	ENSCAFP00000025824	OCIA domain containing 2.	Synaptotagmin like 4.	0.522
PDZD11	STXBP2	ENSCAFP00000057035	ENSCAFP00000027039	PDZ domain containing 11.	Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family.	0.591
PDZD11	SYTL4	ENSCAFP00000057035	ENSCAFP00000025824	PDZ domain containing 11.	Synaptotagmin like 4.	0.567
RAB27A	RAB27B	ENSCAFP00000023411	ENSCAFP00000000213	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	RAB27B, member RAS oncogene family.	0.807
RAB27A	STXBP2	ENSCAFP00000023411	ENSCAFP00000027039	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family.	0.411
RAB27A	SYTL4	ENSCAFP00000023411	ENSCAFP00000025824	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	Synaptotagmin like 4.	0.732
RAB27B	RAB27A	ENSCAFP00000000213	ENSCAFP00000023411	RAB27B, member RAS oncogene family.	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	0.807
RAB27B	SYTL4	ENSCAFP00000000213	ENSCAFP00000025824	RAB27B, member RAS oncogene family.	Synaptotagmin like 4.	0.830
RAB8A	RAB8B	ENSCAFP00000023207	ENSCAFP00000024993	Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...]	RAB8B, member RAS oncogene family.	0.903
RAB8A	SYTL4	ENSCAFP00000023207	ENSCAFP00000025824	Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...]	Synaptotagmin like 4.	0.533
RAB8B	RAB8A	ENSCAFP00000024993	ENSCAFP00000023207	RAB8B, member RAS oncogene family.	Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...]	0.903
RAB8B	SYTL4	ENSCAFP00000024993	ENSCAFP00000025824	RAB8B, member RAS oncogene family.	Synaptotagmin like 4.	0.533
SH3BGRL2	SYTL4	ENSCAFP00000004172	ENSCAFP00000025824	SH3 domain binding glutamate rich protein like 2.	Synaptotagmin like 4.	0.516
STARD10	SYTL4	ENSCAFP00000058799	ENSCAFP00000025824	StAR related lipid transfer domain containing 10.	Synaptotagmin like 4.	0.514
STXBP2	PDZD11	ENSCAFP00000027039	ENSCAFP00000057035	Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family.	PDZ domain containing 11.	0.591
STXBP2	RAB27A	ENSCAFP00000027039	ENSCAFP00000023411	Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family.	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	0.411
STXBP2	SYTL4	ENSCAFP00000027039	ENSCAFP00000025824	Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family.	Synaptotagmin like 4.	0.602
SYTL4	KCNG1	ENSCAFP00000025824	ENSCAFP00000016996	Synaptotagmin like 4.	Potassium voltage-gated channel modifier subfamily G member 1; Belongs to the potassium channel family.	0.530
SYTL4	OCIAD2	ENSCAFP00000025824	ENSCAFP00000052996	Synaptotagmin like 4.	OCIA domain containing 2.	0.522