STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANGPTL8Angiopoietin like 8. (198 aa)    
Predicted Functional Partners:
ANGPTL3
Angiopoietin like 3.
    
 0.991
ANGPTL4
Angiopoietin like 4.
    
 0.969
GPIHBP1
Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1.
     
 0.825
LPL
Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
     
 0.720
HINT2
Histidine triad nucleotide binding protein 2.
      
 0.677
PLEK
Pleckstrin; Major protein kinase C substrate of platelets.
      
 0.631
ANGPTL1
Angiopoietin like 1.
    
 
 0.571
SPAG8
Sperm associated antigen 8.
      
 0.562
APOA5
Apolipoprotein A5.
      
 0.537
GCGR
Glucagon receptor; Belongs to the G-protein coupled receptor 2 family.
      
 0.516
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.