STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SERPINA4Serpin family A member 4; Belongs to the serpin family. (421 aa)    
Predicted Functional Partners:
SSR2
Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.
      
 0.780
KLK1
Peptidase S1 domain-containing protein.
   
 
 0.748
KLK2
Arginine esterase; This serine protease is found in dog seminal plasma, its exact physiological function is not known.
   
 
 0.706
LECT2
Leukocyte cell derived chemotaxin 2.
   
  
 0.576
APOH
Beta-2-glycoprotein 1; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
   
 0.569
SPP2
Secreted phosphoprotein 2.
   
 
 0.548
ITIH3
Inter-alpha-trypsin inhibitor heavy chain 3.
   
 
 0.523
F13B
Coagulation factor XIII B chain.
   
  
 0.495
ITIH4
Inter-alpha-trypsin inhibitor heavy chain 4.
   
 
 0.482
KLK14
Kallikrein related-peptidase 14; Belongs to the peptidase S1 family.
   
 
 0.463
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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