STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GAREM1GRB2 associated regulator of MAPK1 subtype 1. (835 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor bound protein 2.
   
 
 0.720
AMZ1
Archaelysin family metallopeptidase 1.
      
 0.604
RILPL2
Rab interacting lysosomal protein like 2.
   
 
 0.591
FAM167A
Family with sequence similarity 167 member A.
      
 0.564
SH3BP4
SH3 domain binding protein 4.
   
  
 0.536
FADS3
RAB3A interacting protein like 1.
    
 
 0.531
RAB3IP
RAB3A interacting protein.
    
 
 0.531
KRT39
Keratin 39; Belongs to the intermediate filament family.
      
 0.515
VPS16
Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.
    
 
 0.493
B4GALT6
Beta-1,4-galactosyltransferase 6.
      
 0.479
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.