HSP90AA1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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gene co-occurrence

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Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHR	AR	ENSCAFP00000052303	ENSCAFP00000024499	Aryl hydrocarbon receptor.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.414
AHR	ENSCAFP00000044830	ENSCAFP00000052303	ENSCAFP00000044830	Aryl hydrocarbon receptor.	Uncharacterized protein.	0.769
AHR	HSP90AA1	ENSCAFP00000052303	ENSCAFP00000026650	Aryl hydrocarbon receptor.	Heat shock protein 90 alpha family class A member 1.	0.833
AR	AHR	ENSCAFP00000024499	ENSCAFP00000052303	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Aryl hydrocarbon receptor.	0.414
AR	ENSCAFP00000044830	ENSCAFP00000024499	ENSCAFP00000044830	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Uncharacterized protein.	0.767
AR	HSP90AA1	ENSCAFP00000024499	ENSCAFP00000026650	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Heat shock protein 90 alpha family class A member 1.	0.868
AR	HSP90B1	ENSCAFP00000024499	ENSCAFP00000057899	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.918
AR	HSPA4	ENSCAFP00000024499	ENSCAFP00000062263	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	Heat shock 70 kDa protein 4.	0.646
CDC37	ENSCAFP00000044830	ENSCAFP00000057351	ENSCAFP00000044830	Cell division cycle 37.	Uncharacterized protein.	0.831
CDC37	HSP90AA1	ENSCAFP00000057351	ENSCAFP00000026650	Cell division cycle 37.	Heat shock protein 90 alpha family class A member 1.	0.840
CDC37	HSP90B1	ENSCAFP00000057351	ENSCAFP00000057899	Cell division cycle 37.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.986
CDC37	HSPA4	ENSCAFP00000057351	ENSCAFP00000062263	Cell division cycle 37.	Heat shock 70 kDa protein 4.	0.633
CDC37	SUGT1	ENSCAFP00000057351	ENSCAFP00000007201	Cell division cycle 37.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.566
ENSCAFP00000044830	AHR	ENSCAFP00000044830	ENSCAFP00000052303	Uncharacterized protein.	Aryl hydrocarbon receptor.	0.769
ENSCAFP00000044830	AR	ENSCAFP00000044830	ENSCAFP00000024499	Uncharacterized protein.	Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.	0.767
ENSCAFP00000044830	CDC37	ENSCAFP00000044830	ENSCAFP00000057351	Uncharacterized protein.	Cell division cycle 37.	0.831
ENSCAFP00000044830	HSP90AA1	ENSCAFP00000044830	ENSCAFP00000026650	Uncharacterized protein.	Heat shock protein 90 alpha family class A member 1.	0.951
ENSCAFP00000044830	HSP90B1	ENSCAFP00000044830	ENSCAFP00000057899	Uncharacterized protein.	Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity). When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity. Belongs to the heat shock protein 90 family.	0.840
ENSCAFP00000044830	HSPA4	ENSCAFP00000044830	ENSCAFP00000062263	Uncharacterized protein.	Heat shock 70 kDa protein 4.	0.865
ENSCAFP00000044830	HSPA5	ENSCAFP00000044830	ENSCAFP00000029957	Uncharacterized protein.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.681