STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF317Zinc finger protein 317. (598 aa)    
Predicted Functional Partners:
CNDP2
Carnosine dipeptidase 2.
      
 0.789
STX16
t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.
   
  
 0.598
EXOSC8
Exosome component 8.
      
 0.572
DHX15
DEAH-box helicase 15.
   
 
 0.524
CDCA7
zf-4CXXC_R1 domain-containing protein.
    
 
 0.519
TOP1
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
   
 
 0.507
PER2
Period circadian regulator 2.
   
  
 0.487
ACTL6A
Actin like 6A; Belongs to the actin family.
    
 
 0.473
NONO
Non-POU domain containing octamer binding.
   
 
 0.455
MCM10
Minichromosome maintenance 10 replication initiation factor.
   
  
 0.441
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.