STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABCC6ATP binding cassette subfamily C member 6. (1619 aa)    
Predicted Functional Partners:
ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase 1.
   
 
 0.806
GGCX
Gamma-glutamyl carboxylase.
   
 
 0.785
ABCA13
ATP binding cassette subfamily A member 13.
   
 
0.747
ABCF3
ATP binding cassette subfamily F member 3.
   
 
 0.741
CUL7
Cullin 7; Belongs to the cullin family.
   
 
 0.705
SLC13A5
Solute carrier family 13 member 5.
   
 
 0.674
ARID5B
AT-rich interactive domain-containing protein 5B; Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride m [...]
   
  
 0.658
TCTN2
Tectonic family member 2.
   
 
 0.641
ABCG2
ATP binding cassette subfamily G member 2.
   
 
 0.641
ANKH
ANKH inorganic pyrophosphate transport regulator.
   
  
 0.637
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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